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If you have been living under a rock the last several years, you might be forgiven for not knowing just how much the legal hemp and cannabis industry have upended the status quo.

With the total opening of hemp products to the recreational market, CBD has become a massive success, coming on the heels of multiple states opening up their marketplaces for legalized marijuana in the last five years.

To even the most untrained eye, you can see where this is going; it is only a matter of time before the entire country is opened up to cannabis in any form: marijuana plant and hemp alike. 

This has flooded the zone with spinoff products derived from cannabis, to sometimes mixed reception.

Delta-8, for example, has attracted controversy in multiple states due to its psychoactivity and has been pulled from the marketplace in various states as of this writing.

On the flipside, advertisements for weed gummies and CBD cocktails line the streets of Las Vegas and Southern California. So what is the next frontier for cannabis? 

It turns out it’s a little-known cannabinoid called THCV. In the absence of THC gummies in some states, THCV is in the beginning stages of establishing itself as a “diet weed.”

In other words, THCV has the potential to be a THC-derived product that does not induce psychoactivity but has benefits that go above and beyond the well-established benefits of both THC and CBD.

We will get into these THCV effects on today’s blog and hope to introduce you to a new way to benefit from the magic forms of cannabis. 

THCV Energy: This Is Not CBD

The first thing to know about THCV is that while it is a cannabinoid, there is little about its effects on the human body that would make one associate it with its better-known counterparts, THC, and CBD. THCV is unique in this sense.

Its functions within the human body go beyond the stereotypical, well-known benefits of THC and CBD. 

This is partly due to the way THCV attaches itself to the body’s cannabinoid receptors. To recap, what this means: every mammal has what we call an endocannabinoid system.

This system functions independently without the need for “foreign” cannabinoids even to enter it. Instead, our body has its cannabinoid molecules that attach themselves to our body’s receptors (named CB1 and CB2). 

So, when you take THC or CBD, the molecules of these cannabinoids overwhelm the body’s natural production, resulting in their famous effects – the good and bad.

THC is deemed a partial agonist at the CB1 receptor, meaning it overwhelms this receptor and enhances the impact at this receptor – causing the euphoria, appetite increase, decompressing, and sedative effects it is famous for.

While far more subtle in its effects, CBD does the same thing as an antagonist, meaning it counteracts the activity of the receptor. This explains why high levels of CBD in a marijuana product counteract the psychoactive effects of THC.

That brings us to THCV, which is a partial antagonist/agonist at the CB2 receptor, meaning its psychoactivity depends on the dose.

It is theorized that the dosage here is the indicator by which THCV can induce psychoactive effects or not.

More specifically studied, however, is the effect THCV has on energy levels, and on this front, THCV has shown promise. 

As an antagonist, it up-regulates energy levels and creates a clear-headed mood in its users. This has a similar potential to CBD, which “levels out” the body’s processes through homeostasis.

THCV does not necessarily encourage homeostasis, but targets the human body’s metabolism, regulating glucose levels and increasing alertness at the receptors. This process is still being studied as we speak.

The bottom line is that you can expect increased energy and attention through concentrated doses of THCV. 

THCV Appetite Suppressant: The Unexpected Upsides

The status of THCV as an agonist at the critical receptors that govern the body’s appetite and metabolic response is crucial to THCV’s quality as an appetite suppressant.

CB1 receptors control the body’s hunger response hormone, and THCV’s blockage at this receptor is what has given THCV the potential to be a breakthrough as a weight-loss or diet supplement/supporting compound. 

Familiar with hunger pains? THCV also suppresses these, one of the more cumbersome symptoms of dieting, while the body struggles to adjust to new eating patterns and schedules.

These out of the equation makes lifestyle changes that much easier. 

THCV is present in only some forms of cannabis, specifically, the “Sativa” strains of marijuana, which tend to provide “head highs,” more so better for creativity and energy boost.

This differs from the sedating, pain-decreasing, euphoric mood that mainstream strains of marijuana typically provide. 

Real-world evidence of this exists in animal studies, one of which recorded responses in groups of mice that ingested THC and THCV.

The results showed a reversal in behaviors related to appetite, and marked weight loss was recorded as well.  

THCV and Blood Sugar

THCV’s effect on the body’s processes extends to the world of blood sugars.

Americans deal with a Type 2 diabetes epidemic these days, so any substance or compound capable of keeping that at bay for any one individual is a definite win for the health of many individuals. 

How does this work? In the United Kingdom, there was a clinical trial involving THCV that looked at subjects suffering from type 2 diabetes.

Subjects were given THCV for 13 weeks vs. a placebo control group, and the findings were welcome and surprising.

Over that period, a significant decrease in fasting glucose was recorded. On the other hand, placebo subjects or those taking mere CBD showed no progress. 

The significance of this is hard to overstate; you may recall CBD’s breakthrough status in this country after it got approved as a medication for patients who have epilepsy.

Whether a similar outcome is in store for THCV remains to be seen, but here at PureKana, we remain hopeful that cannabis products can change our lives. 

What Kind of THCV Products Are Out There?

So far, there are not a massive number of options available in terms of THCV. As of this writing, THCV edibles dominate the possibilities.

Much like THC gummies are the favored “first venture” of those seeking to experiment with THC, THCV gummies seem to be the best way forward right now.

However, because of the limited quantity of products, it will take us a while to understand which brand provides the best edibles. 

THCV gummies come in 10 mg doses for the most part, with low sugar, sometimes in an isolated form, other times combined with CBD or Delta 8 THC. 

Tinctures are also available, and as of this writing, the tincture available on the market comes in a spray, with about 6.7 MG of THCV per serving.

If this sounds low, it may be because the market is still getting a sense of what the proper dosing of THCV should look like. Expect this to change and evolve as more brands get their hands on THCV in the coming months. 

Sources:

https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-020-0016-7

https://cannabigold.co.uk/knowledge-center/how-cbd-interacts-with-the-endocannabinoid-system-2/

https://www.cannamd.com/marijuana-blood-pressure-what-we-know/

https://www.cannamd.com/thcv-everything-you-need-to-know/

https://norml.org/news/2017/01/26/clinical-trial-thcv-lowers-blood-sugar-levels-in-type-2-diabetics/

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