Skip to main content

Most people have heard of THC and CBD and their beneficial health effects, but did you know that there are over 100 other cannabinoids found in the cannabis plant?

Recently another non-psychoactive cannabinoid has been trending for its potential therapeutic effects: CBG. 

CBG binds to both cannabinoid receptors to strengthen and increase the function of Anandamide, a neurotransmitter that plays a role in regulating functions like sleep.

More research on CBG is still needed to determine just how beneficial the cannabinoid can be.

However, the potential pharmacological properties are currently being examined, showing positive conclusions. Before discussing the relationship between CBG and sleep, we need to understand CBG.

What is CBG?

CBG — or Cannabigerol — is the most abundant non-intoxicating cannabinoid found in cannabis. Because other Cannabinoids are derived from Cannabigerolic Acid (CBGA), CBG is often referred to as the “Mother of all Cannabinoids.” 

CBG is found in smaller quantities than other cannabinoids in cannabis plants. For example, CBG only makes up about 1% of the plant in most strains compared to 20 to 25% CBD or 25 to 30% THC.

As the plant develops, the CBG converts to CBD and THC.

Unlike CBD, which has a relatively low affinity for cannabinoid receptors and acts mainly through indirect interactions with the Endocannabinoid System, CBG has been observed to induce its therapeutic effects through direct interaction with both the CB1 and CB2 cannabinoid receptors in the body.

These receptors regulate physiological processes such as appetite, anxiety, hormones, inflammation, pain, sleep, and immune system responses.

CBG For Sleep 

CBG, in particular, binds to both cannabinoid receptors and amplifies the effects of Anandamide, a neurotransmitter known as the “bliss molecule.”

Anandamide is a cannabinoid that occurs naturally in the body and helps regulate body functions. Special functions held by this cannabinoid include sleep, appetite, and memory. 

In addition to this, CBG specifically has been shown to reduce stress levels on a molecular level by interacting with your body’s Endocannabinoid System (ECS).

When CBG is introduced into the body, neurons in the Central Amygdala, where anxiety and stress are controlled, become less active. In stressful situations, the ECS works to restore your body’s normal homeostasis, which in this case is relieving unease by secreting other neurotransmitters, like Serotonin.

So if stress is making it difficult for you to get a good night’s rest, CBG might be a suitable cannabinoid for you. The Serotonin boost might even help improve your overall mood.

Furthermore, a study conducted in 1975 found that CBG exhibited properties that suggested: “possible utilization as a muscle relaxant in spasticity.”

CBG (Cannabigerol) Explained | Leafly

CBG Benefits

Despite being discovered almost sixty years ago, CBG research has progressed slowly because of its low concentration in cannabis plants.

As a result, while there is an abundance of awareness around the significant cannabinoids THC and CBD, less is known about CBG.

However, new studies have begun uncovering the extract’s therapeutic properties and potential medical uses in recent years. 

Though the benefits of CBG are still not fully understood, some evidence does suggest that it may help treat several conditions.

In 2008, a study published by the neurologist, Dr. Ethan B Russo investigated Cannabinoids in the management of difficult to treat pain.

He determined that: “CBG has more potent analgesic, anti-erythema, and lipoxygenase blocking activity than THC.” Meaning that CBG might be an effective way to treat and manage pain without any of the psychoactive effects of THC.

A study conducted in 2016 also concluded that CBG had appetite-stimulating effects.

Lab rats dosed with CBG were able to eat twice the amount of food compared to the control group. Appetite stimulation can be helpful for those who struggle with appetite loss. 

Another 2020 study examined the antibiotic potential of CBG.

Again, the findings were that CBG has these properties, especially against methicillin-resistant strains of Staphylococcus aureus (MRSA), a drug-resistant bacteria that causes staph infections.

There are many other reported benefits of CBG usage; however, human-based clinical research is limited.

CBG Side Effects 

Before adding CBG to your routine, it is important to understand any potential side effects beforehand. This will allow you to manage your routine more effectively and be more prepared to determine the best regimen. 

CBG has not been shown to have any side effects when taken in therapeutic doses.

However, you may experience adverse side effects if you consume too much. CBG would only become a problem if taken more than 300 milligrams per kilogram of body weight.


A common side effect of using a CBG is diarrhea. This is probably due to the digestive system telling your body that it does not need such a high volume of CBG.

Diarrhea might be at a higher risk when consuming CBG in the form of an edible since this method allows the CBG to interact directly with the digestive tract.


Fatigue is another common side effect of CBG use. Taking an excessive amount of CBG may cause grogginess and tiredness.

However, because many use CBG as a sleep aid, exhaustion and fatigue might be welcomed side effects when consuming the cannabinoid. Just make sure to avoid operating a vehicle if you feel you might be feeling this side effect.

Dry Mouth

Finally, consuming CBG may affect your ability to produce saliva, causing dryness or “cottonmouth.”

This is due to the interaction between the CBG and the Cannabinoid receptors in our salivary glands.

Despite what many people might assume, this is not a sign of dehydration. Although drinking plenty of water is still a good idea nonetheless.

For now, research into CBG is still limited. Meaning, despite growing interest in the potential benefits, very little is known about its side effects or how it works alongside other medications.

Even at dispensaries in states where cannabis is legal, CBG can be difficult to find.

There is also often a quality issue with CBG, so consumers are always advised to check with third-party certifications for the correct concentration level.

At PureKana, you can shop confidently, knowing that the CBG products you are buying have undergone rigorous testing to ensure you are always getting the best quality.


Anandamide modulates sleep and memory in rats

The Pharmacological Case for Cannabigerol

Cannabinoid Regulation of Fear and Anxiety: an Update,degradation%20by%20FAAH%20%5B66%5D.

Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes

Cannabinoids in the management of difficult to treat pain

Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats

Uncovering the Hidden Antibiotic Potential of Cannabis

Leave a Reply